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Grant#

STUDY DESCRIPTION

Award

2005

 
1.  

The First ACKCSC Breed Health Survey

Purdue University - Funded by the ACKCSC Charitable Trust

$ 22,922.24
2.

#423

Evaluation of Objective Structural and Functional Measurements for Predicting Clinical Disease Progression And Assessing Treatment in Cavalier King Charles Spaniels With Caudal Occipital Malformation Syndrome

Ohio State University - Funded by the ACKCSC Charitable Trust

$ 15,355.00
3.  Adobe PDF file icon 32x32

The Effect of Chiari I Malformation on CSF Flow in Cavalier King Charles Spaniels

NC State University - Funded by the ACKCSC Charitable Trust

$ 20,000.00
2006

 

4.

Alteration in Protein Expression in Canine Myxomatous Mitral Valve Disease

University of Edinburgh, Scotland - Donation to this research by the ACKCSC Charitable Trust

$   6,480.00
5.

Diagnosis of Primary Secretory Otitis Media in the Cavalier King Charles Spaniel

Ohio State University - Funded by the ACKCSC Charitable Trust

$ 53,958.00
6.

Mitral Valve Disease in Cavalier King Charles Spaniels

University of Pennsylvania - Funded by the ACKCSC Charitable Trust

Note:  Research began Sept. 1, 2006 with funds from an anonymous donor of $80,000.00

$ 63,446.00
7.

 #779

CHF Link2

Characterization of the Canine Y Chromosome: Identifyiing Genes that Cause Male Infertility

Texas A & M University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$      500.00
8.

 #759

CHF Link2

Investigation of Antigenic Causes of Vaccine Associated Allergic Reaction in Dogs

Purdue University - Funded in cooperation with AKC Canine Health Foundation And other Parent Clubs.

$      500.00
2007
9.

#806A

CHF Link2

Alteration in Protein Expression in Canine Myxomatous Mitral Valve Disease

University of Edinburgh

$   6,480.00
10.

#858

CHF Link2

Evaluation of Novel Diagnostic and therapeutic Modalities  for Treatment of Canine Pulmonary Hypertension

University of Missouri - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$   1,000.00
2008
11.

#954

CHF Link2

Identification of Genes Causing Chiari I Malformation with Syringomelia in the Cavalier King Charles Spaniel

University of Montreal - Funded in cooperation with the AKC Canine Health Foundation

$ 25,000.00
12.

#613

CHF Link2

The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma

North Carolina State University.  Funded in Cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$  2,500.00
13.

#1026A

CHF Link2

Molecular Characterization of Valvular Interstatial Cells in Canine Chronic Valvular Disease

Washington State University - Funded in Cooperation With the AKC Canine Health Foundation and other Parent Clubs.

$ 2,500.00
14.

The Rabies Challenge Fund

Donation from the ACKCSC Charitable Trust

$ 3,000.00
2009
15.

#1004

CHF Link2

Syringomyelia in the Brussels Griffon: Magnetic Resonance Imaging Findings, Clinicopathology, and Prevalence

University of Georgia.  Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs.

Although this research is for Brussels Griffons, the Trustees believe that   anything we can learn from any research on SM may also be useful to Cavaliers.  The findings in this study of similarities or differences may be helpful in our future SM research.

$  5,000.00
16.

#1226

CHF Link2

Evaluation of Multidrug Resistance Genes in Primary Canine Lymphoma Cells Exposed to Enrofloxacin and Predisolone

Auburn University.  Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs

This research may result in changes in the management of patients with lymphoma or suspected lymphoma regarding steroid and antibiotic treatment.

Based on our Health Survey done in 2004 – 2005, cancer was the number two cause of death in Cavaliers.  The Trustees believe that cancer research is very  important to our breed.

$    500.00
17.

#1232A

CHF Link2

Investigation of NF-kB as aTherapeutic Target in Canine Lymphoma

University of Pennsylvania – School of Veterinary Medicine.  Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$    500.00
18.

 #1240A

CHF Link2

Development of a Diagnostic Method for Canine Atopic Dermatitis

Imulan Bio Therapeutics - Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs.

This research hopes to develop a simple blood test to detect whether or not particular dog is hyper-reactive to its own immune cells.

$    500.00
19.

 #1344A

CHF Link2

Comparison of Percentage of T Regulatory Cells in Dogs with Spontaneously Occurring Lymphoma Following Oral Versus Intravenous Cyclophosphamide 

University of Missouri, Columbia - Funded in cooperation with the AKCCanine Health Foundation and other Parent Clubs.

$    500.00
20.

#615B

CHF Link2

Heritable and Sporadic Genetic Lesions in Canine Lymphoma

North Carolina State University - Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs.

This research will set the groundwork to identify specific genes associated  with breed-dependent cancer risk. 

$  2,500.00
21.

#768

CHF Link2

A Collaborative Study by Veterinary Oncologists, Pathologists and Diagnostic Laboratories to Enhance the Detection, Diagnosis and Treatment  of Canine Lymphoma

University of Illinois - Funded in Cooperation with the AKC Canine Health Foundation and other Parent Clubs.

This research has the potential to alter costs of treatment according to tumor type and increase survival. 

$  1,000.00
22.

#908

CHF Link2

Seratonin Type2A Receptor Antagonist Therapy for Preventing the Progression of Myxomatous Mitral Valve Disease

University of Pennsylvania School of Veterinary Medicine - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

This proposal represents a novel translational study that targets a potential underlying pathogenesis of canine mitral valve disease. 

$  5,000.00
23.

#856A

CHF Link2

Effect of Treatment with Low Doses of Hydrocortisone on Blood Pressure and Mortality in Dogs with Septic Shock

University of California, Davis School of Veterinary Medicine - Funded in cooperation with the AKC Canine Health Foundation And other Parent Clubs.

$     500.00
24.

#970

CHF Link2

Tissue Regeneration using Canine Mesenchymal Stem Cells: Effects of Donor Characteristics and ex vivo Expansion on Cell Pluripotency

University of Pennsylvania School of Veterinary Medicine - Funded in cooperation With the AKC Canine Health Foundation and other Parent Clubs.

This research will bring promising stem cell therapies closer to reality in veterinary medicine including new therapies for heart failure. 

$   2,500.00
 25.

#1231

CHF Link2

Prevalence and Localization of Bartonella spp. In Vascular Tumors from Dogs

North Carolina State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

This research will facilitate the development of tests that can be used to establish the cellular localization of Bartonella in the diseased tissues of infected dogs. 

$   1,000.00
26.

#1352

CHF Link2

Detection of Brucella canis DNA in Canine Urine, Semen and Vaginal Cells via qPCR Analysis

Iowa State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

Currently there is no early detection testing available for this disease.  This research hopes to develop a test that will detect the disease earlier than traditional culture and serology.

$     500,00
27.

Investigation of the presence of Chiari-like Malformation and Syringomelia in Stillborn Cavalier King Charles Foetuses  

The Royal Veterinary College, U.K.- Donation by the ACKCSC Charitable Trust

$ 15,000.00
2012
28.

#105

 

Role of Morphology in Clinical Progression and Syringomyelia in CKCS Chiari-Like Malformation

Cornell University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$ 22,943.00
29.

 #106

 

MRI Evaluation Chiari-like malformation and its association with BEAR Testing

Ohio State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

 $ 21,000.00
30.

 #107

 

Development and Testing of a Novel Canine Annuloplasty Ring for Mitral Valve Repair

Michigan State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$ 13,980.00
2013
31.

#01866

CHF Link2

Enhancing Treatment of Mitral Valve Disease Through Identification of the Biological Markers of the Disease

Texas A & M - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs

$  2,500.00
2014
32.

#01994

CHF Link2

Early and Accurate Prediction of Mitral Valve Disease Development

Cornell University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$  2,500.00

 

OPEN

33.

#2131

CHF Link2

Neurostimulation: A Groundbreaking New Treatment for Canine Epilepsy

University of Melborne

OPEN

34.

 #2133

CHF Link2

Canine Epilepsy: Genetic Variants, Biomarkers and New Therapies (Phase 1)

University of Minnesota - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$10,000.00 

 

OPEN

35.

#02123

CHF Link2

Identifying the gene Responsible For Inherited Infertility and Sterility in 28 Breeds

Cornell University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

 

OPEN

 36.

 #02124

CHF Link2

Determining the Characteristics of Sperm That Accurately Predict Fertility

University of California, Davis - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs.

$ 12,960.00

 OPEN

 2015
 37.

 #2162

CHF Link2

Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog

North Carolina State University - Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs.

 

OPEN

 38.  

The Second ACKCSC Breed Health Survey

???????? - Funded by the ACKCSC Charitable Trust

OPEN

 39.

CHF Link2

 40.

CHF Link2

41.

CHF Link2

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