2020

2019

• Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease  - North Carolina State University - Funded  by in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($5,000.00-CLOSED) CHF Grant #2436.  Report 
  
• Three Dimensional Echocardiographic Determinants of the age of onset of Myxomatous Mitral Valve Disease in CKCS - Virginia-Maryland Regional College of Veterinary Medicine - Funded by in cooperation with the AKC CHF, ACKCSC and Other Parent Clubs ($5,000.00-OPEN) CHF Grant #2649.  5/1/19 - 4/30/22.**

2018

• Predicting Disease Stage and Diuretic Responsiveness in Dogs with Acquired Heart Disease - North Carolina State University - Funded  by in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($5,000.00-CLOSED) CHF Grant #2436.    5/1/18-10/31/19.

2017

• Developing A Novel Cardio-Protective Gene Therapy to Stop the Progression of HeartFailure in Dogs. - Rejuvenate Bio - Funded and in Partnership with American Cavalier King Charles Spaniel Club

           ($100,000.00-Open) ACKCSC Grant #107.5/1/2017-3/20/21*

            2017-2019 - Safety Study in Beagles and Development of Treatment Dosage

            2020-2021 - Pilot Efficacy Study in Cavalier King Charles Spaniels

2016

• Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog - North Carolina State University - Funded  by in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($37,530.00-Closed } CHF Grant #2162. Publications 1 Publications 2 Publications 3 Publications 4(1/1/15 - 3/31/20)

2015

• Defining The Genetic Foundations of Chiari-Like Malformation and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog - North Carolina State University - Funded  by in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($41,256.00-Closed) CHF Grant #2162. Publications 1 Publications 2 Publications 3 (1/1/15 - 3/31/20)
  
  
• The Second ACKCSC Breed Health Survey - Funded by the ACKCSC Charitable Trust (OPEN)

2014

• Defining the Genetic Foundation of Chiara-Like Malformations and Syringomyelia as a Tool to Better Treat Neuropathic Pain in the Dog Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,000-OPEN) CHF Grant #2162. Publications 1 Publications 2 Publications 3
  
  
• Determining the Characteristics of Sperm That Accurately Predict Fertility of Stud Dogs.Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,000-OPEN) CHF Grant 02124-A  Article
  
  
• Identifying the Gene Responsible for Inherited Infertility and Sterility in 28 Breeds.Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,000-OPEN) CHF Grant #02123-A Article  related grants
  
  
• Targeting the Mechanism of Bacterial Adherence during Pyometra to Develop an Effective Non-Invasive Treatment for Disease Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,000-OPEN) CHF Grant #02118-A10210
  
  
• Epilepsy Initiative Charter Sponsor -Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($10,000-OPEN) CHF Research Initiative
  
  
• Early and Accurate Prediction of Mitral Valve Disease Development - Cornell University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,500-OPEN) CHF Grant #01994
  
  
• Neurostimulation: A Groundbreaking New Treatment for Canine Epilepsy - University of Melborne (OPEN) CHF Grant #2131.

• Canine Epilepsy: Genetic Variants, Biomarkers and New Therapies (Phase 1) - University of Minnesota - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($10,000 - OPEN) CHF Grant #2133.
• Identifying the gene Responsible For Inherited Infertility and Sterility in 28 Breeds - Cornell University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs (OPEN) CHF Grant #02123.
  
  
• Determining the Characteristics of Sperm That Accurately Predict Fertility - University of California, Davis - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($12,960-OPEN) CHF Grant #02124.

2013

• Enhancing Treatment of Mitral Valve Disease Through Identification of the Biological Markers of the Disease- Texas A & M - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($2,500) CHF Grant #01866.

2012

• Role of Morphology in Clinical Progression and Syringomyelia in CKCS Chiari-Like Malformation - Cornell University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($22,943) CHF Grant #105.
  
  
• MRI Evaluation Chiari-like malformation and its association with BAER Testing - Ohio State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($21,000) CHF Grant #106.
  
  
• Development and Testing of a Novel Canine Annuloplasty Ring for Mitral Valve Repair - Michigan State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($13,980) CHF Grant #107.

2009

• Syringomyelia in the Brussels Griffon: Magnetic Resonance Imaging Findings, Clinicopathology, and Prevalence- University of Georgia.  Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($5,000). CHF Grant #1004 - Note: Although this research is for Brussels Griffons, the Trustees believe that anything we can learn from any research on SM may also be useful to Cavaliers.  The findings in this study of similarities or differences may be helpful in our future SM research.
  
  
• Evaluation of Multidrug Resistance Genes in Primary Canine Lymphoma Cells Exposed to Enrofloxacin and Predisolone - Auburn University.  Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($500). CHF Grant #1226 - Note: This research may result in changes in the management of patients with lymphoma or suspected lymphoma regarding steroid and antibiotic treatment. Based on our Health Survey done in 2004 – 2005, cancer was the number two cause of death in Cavaliers.  The Trustees believe that cancer research is very  important to our breed.
  
  
• Investigation of NF-kB as aTherapeutic Target in Canine Lymphoma - University of Pennsylvania – School of Veterinary Medicine.  Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($500). CHF Grant #1232A
  
  
• Development of a Diagnostic Method for Canine Atopic Dermatitis - Imulan Bio Therapeutics - Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($500) CHF Grant #1240A - Note: This research hopes to develop a simple blood test to detect whether or not particular dog is hyper-reactive to its own immune cells.
  
  
• Comparison of Percentage of T Regulatory Cells in Dogs with Spontaneously Occurring Lymphoma Following Oral Versus Intravenous Cyclophosphamide - University of Missouri, Columbia - Funded in cooperation with the AKCCanine Health Foundation and other Parent Clubs ($500) CHF Grant #1344A.
  
  
• Heritable and Sporadic Genetic Lesions in Canine Lymphoma - North Carolina State University - Funded in cooperation with the AKC Canine Health Foundation and Other Parent Clubs ($2,500) CHF Grant #615B. Note: This research will set the groundwork to identify specific genes associated  with breed-dependent cancer risk.
  
  
• A Collaborative Study by Veterinary Oncologists, Pathologists and Diagnostic Laboratories to Enhance the Detection, Diagnosis and Treatment  of Canine Lymphoma - University of Illinois - Funded in Cooperation with the AKC Canine Health Foundation and other Parent Clubs ($1,000) CHF Grant #768. Note: This research has the potential to alter costs of treatment according to tumor type and increase survival. 
  
  
• A Collaborative Study by Veterinary Oncologists, Pathologists and Diagnostic Laboratories to Enhance the Detection, Diagnosis and Treatment  of Canine Lymphoma - University of Illinois - Funded in Cooperation with the AKC Canine Health Foundation and other Parent Clubs ($1,000) CHF Grant #768. Note: This research has the potential to alter costs of treatment according to tumor type and increase survival. 
  
  
• Seratonin Type2A Receptor Antagonist Therapy for Preventing the Progression of Myxomatous Mitral Valve Disease - University of Pennsylvania School of Veterinary Medicine - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($5,000) CHF Grant #908. Note: This proposal represents a novel translational study that targets a potential underlying pathogenesis of canine mitral valve disease. 
  
  
•  Effect of Treatment with Low Doses of Hydrocortisone on Blood Pressure and Mortality in Dogs with Septic Shock - University of California, Davis School of Veterinary Medicine - Funded in cooperation with the AKC Canine Health Foundation And other Parent Clubs ($500) CHF Grant #856A
  
  
• Tissue Regeneration using Canine Mesenchymal Stem Cells: Effects of Donor Characteristics and ex vivo Expansion on Cell Pluripotency - University of Pennsylvania School of Veterinary Medicine - Funded in cooperation With the AKC Canine Health Foundation and other Parent Clubs ($2,500)  CHF Grant #970. Note: This research will bring promising stem cell therapies closer to reality in veterinary medicine including new therapies for heart failure. 
  
  
• Prevalence and Localization of Bartonella spp. In Vascular Tumors from Dogs - North Carolina State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($1,000) CHF Grant #1231. Note: This research will facilitate the development of tests that can be used to establish the cellular localization of Bartonella in the diseased tissues of infected dogs.
  
  
• Detection of Brucella canis DNA in Canine Urine, Semen and Vaginal Cells via qPCR Analysis - Iowa State University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs ($500) CHF Grant #1352. 
  Note: Currently there is no early detection testing available for this disease.  This research hopes to develop a test that will detect the disease earlier than traditional culture and serology.
  
  
• Investigation of the presence of Chiari-like Malformation and Syringomelia in Stillborn Cavalier King Charles Foetuses  - The Royal Veterinary College, U.K.- Donation by the ACKCSC Charitable Trust ($15,000).

2008

• Identification of Genes Causing Chiari I Malformation with Syringomelia in the Cavalier King Charles Spaniel - University of Montreal - Funded in cooperation with the AKC Canine Health Foundation ($25,000) CHF Grant #954
  
  
• The Prognostic Significance of Chromosome Aneuploidy in Canine Lymphoma - North Carolina State University.  Funded in Cooperation with the AKC Canine Health Foundation and other Parent Clubs. ($2,500) CHF Grant #613
  
  
• Molecular Characterization of Valvular Interstatial Cells in Canine Chronic Valvular Disease - Washington State University - Funded in Cooperation With the AKC Canine Health Foundation and other Parent Clubs.($2,500) CHF Grant #1026A
  
  
• The Rabies Challenge Fund - Donation from the ACKCSC Charitable Trust ($3,000)

2007

• Alteration in Protein Expression in Canine Myxomatous Mitral Valve Disease - University of Edinburgh ($6,480) CHF Grant #806A
  
  
• Evaluation of Novel Diagnostic and therapeutic Modalities  for Treatment of Canine Pulmonary Hypertension - University of Missouri - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs. ($1,000). CHF Grant #858

2006

• Alteration in Protein Expression in Canine Myxomatous Mitral Valve Disease - University of Edinburgh, Scotland - Donation to this research by the ACKCSC Charitable Trust ($6,480)
  
  
• Diagnosis of Primary Secretory Otitis Media in the Cavalier King Charles Spaniel - Ohio State University - Funded by the ACKCSC Charitable Trust ($53,958)
  
  
• Mitral Valve Disease in Cavalier King Charles Spaniels - University of Pennsylvania - Funded by the ACKCSC Charitable Trust ($63,446). Note:  Research began Sept. 1, 2006 with funds from an anonymous donor of $80,000.00
  
  
• Characterization of the Canine Y Chromosome: Identifyiing Genes that Cause Male Infertility - Texas A & M University - Funded in cooperation with the AKC Canine Health Foundation and other Parent Clubs (Grant #779) ($500) CHF Grant #779
  
  
• Investigation of Antigenic Causes of Vaccine Associated Allergic Reaction in Dogs - Purdue University - Funded in cooperation with AKC Canine Health Foundation And other Parent Clubs (Grant #759) ($500). CHF Grant #759

2005

• The First ACKCSC Breed Health Survey - Purdue University - Funded by the ACKCSC Charitable Trust ($22,922.24)
  
  
• Evaluation of Objective Structural and Functional Measurements for Predicting Clinical Disease Progression And Assessing Treatment in Cavalier King Charles Spaniels With Caudal Occipital Malformation Syndrome - Ohio State University - Funded by the ACKCSC Charitable Trust ($15,355.00) (Grant #423)
  
  
• The Effect of Chiari I Malformation on CSF Flow in Cavalier King Charles Spaniels - NC State University - Funded by the ACKCSC Charitable Trust ($20,000)